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KMID : 0367020090210050477
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Journal of Korean Academic of Adult Nursing
2009 Volume.21 No. 5 p.477 ~ p.488
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Cardiovascular Risk Factors Predicting Endothelial Dysfunction in Patients with Variant Angina
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Cho Sook-Hee
Hwang Seon-Young
Jeong Myung-Ho
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Abstract
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Purpose: This study was conducted to identify the clinical characteristics and risk factors on the occurrence of variant angina, and to examine the predicting factors on the vascular endothelial dysfunction of the patients with variant angina.
Methods: A total of 134 patients diagnosed with variant angina were recruited from 2006 to 2008. The degrees of endothelial dysfunction were measured and recorded by the researcher using the values of flow-mediated vasodilation of their brachial arteries and Nitroglycerine-mediated dilation. Subjects’ demographic data and risk factors were gathered after obtaining informed consent, and their electronic medical records were reviewed to collect laboratory data.
Results: The mean age was 54.2 ± 9.6 years and 52% was male patients. More than 50% of the male patients were cigarette smokers and had hypercholesterolemia. 84% of the male patients and 70% of the female patients had more than one risk factor of cardiovascular disease. A stepwise multiple regression analysis showed that smoking and hypercholesterolemia predicted the decrease of flow-mediated vasodilation (Adjusted R2 = .204, p < .001).
Conclusion: Tailored educational interventions for smoking cessation and cholesterol management are needed to prevent recurrence of angina attack for patients with variant angina and to prevent cardiovascular disease for middle-aged workers.
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KEYWORD
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Variant angina pectoris, Smoking, Hypercholesterolemia
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